Publications
The outcomes of our research
Scientific papers
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Ukleja M, Kricks L, Torrens G, Peschiera I, Rodrigues-Lopes I, Krupka M, García-Fernández J, Melero R, del Campo R, Eulalio A, Mateus A, López-Bravo M, Rico AI, Cava F and Lopez D.
Flotillin-Mediated Stabilization of Unfolded Proteins in Bacterial Membrane Microdomains (2024).
DOI: https://doi.org/10.1038/s41467-024-49951-1
Nature Communications 15:5583 - Adolf LA, Müller-Jochim A, Kricks L, Puls JS, Lopez D, Grein F, Heilbronner S*.
Functional membrane microdomains and the hydroxamate siderophore transporter ATPase FhuC govern Isd-dependent heme acquisition in Staphylococcus aureus
DOI: https://doi.org/10.7554/eLife.85304
eLife 12: e85304 (2023)
- Wessel AK, Yoshii Y, Reder A, Boudjemaa R, Szczesna M, Betton JM, Bernal-Bayard J, Beloin C, Lopez D, Völker U, b and JM Ghigo*. Escherichia coli SPFH Membrane Microdomain Proteins HflKC Contribute to Aminoglycoside and Oxidative Stress Tolerance
DOI: https://doi.org/10.1128%2Fspectrum.01767-23
Microbiology Spectrum 11: e01767-23 (2023).
- Garcia J, Cordero M, Acosta IC, Yepes A, Avendano J, Lisowski C, Osterreicht B, Ohlsen K, Lopez-Collazo E, Föstner KU, Eulalio A and Lopez D*. The Induction of Natural Competence Adapts Staphylococcal Metabolism to Infection
DOI: https://doi.org/10.1038/s41467-022-29206-7
Nature Communications 13:1525 (2022)
- Bencurova E, Shityakov S, Schaack D, Kaltdorf M, Sarukhanyan E, Hilgarth A, Rath C, Montenegro C, Roth G, Lopez D, Dandekar T*. Nanocellulose Composites as Smart Devices With Chassis, Light-Directed DNA Storage, Engineered Electronic Properties, and Chip Integration
DOI: https://doi.org/10.3389/fbioe.2022.869111
Frontiers in Bioengineering and Biotechnology 10:869111 (2022)
- Rodrigues Lopes I, Alcantara LM, Silva RJ, Josse J, Pedrero Vega E, Cabrerizo AM, Bonhomme M, Lopez D, Laurent F, Vandenesch F, Mano M, Eulalio A*.
Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature
DOI: https://doi.org/10.1038/s41467-022-34790-9
Nature Communications 13:7174 (2022)
- Mietrach N., Damián-Aparicio D., Mielich-Süß B., López D., and Geibel S.
Substrate interaction with the EssC coupling protein of the Type VIIb secretion system
DOI: https://doi.org/10.1128/JB.00646-19
Journal of Bacteriology 202(7): e00646-19 (2020)
- García-Betancur J. C. and Lopez D.
Cell Heterogeneity in Staphylococcal Communities
DOI: https://doi.org/10.1016/j.jmb.2019.06.011
Journal of molecular biology 431(23):4699-4711 (2019)
- Alcorlo M., Dik D., De Benedetti S., Mahasenan K., Lee M., Dominguez-Gil T., Hesek D., Lastochkin E., Lopez D., Boggess W., Mobashery S., and Hermoso J.
Structural basis of denuded glycan recognition by SPOR domains in bacterial cell division
DOI: https://www.nature.com/articles/s41467-019-13354-4
Nature communications 10:5567 (2019)
- Mielich-Suss B and Lopez D.
Molecular mechanisms involved in Bacillus subtilis biofilm formation
DOI: https://doi.org/10.1111/1462-2920.12527
Environmental Microbiology (2015) 17:555-565
- Feng X, Hu Y, Zheng Y, Zhu W, Li K, Huang CH, Ko TP, Ren F, Chan HC, Nega M, Bogue S, Lopez D, Kolter R, Götz F, Guo RT and Oldfield E.
Structure and function of Bacillus subtilis YisP: Biofilm production by a YisP product
DOI: https://doi.org/10.1016/j.chembiol.2014.08.018
Cell Chemical Biology (2015) 21: 1557-1563
- Schneider J, Klein, T, Mielich-Süß B, Franze C, Kuipers O, Kovacs A, Sauer M and Lopez D.
Spatio-temporal remodeling of bacterial functional membrane microdomains
DOI: https://doi.org/10.1371/journal.pgen.1005140
PLoS Genetics (2015) 11: e1005140
- Bramkamp M and Lopez D.
Exploring the existence of lipid rafts in bacteria
DOI: https://doi.org/10.1128/MMBR.00036-14
Microbiology and Molecular Biology Reviews (2015) 79: 81-100
- Lopez D.
Molecular composition of functional microdomains in bacterial membranes
DOI: https://doi.org/10.1016/j.chemphyslip.2015.08.015
Chemistry and Physics of Lipids (2015) 192: 3-11
- Espina L, Pagán R, López D and García-Gonzalo D.
Individual Constituents from Essential Oils Inhibit Biofilm Mass Production by Multi-Drug Resistant Staphylococcus aureus
DOI: https://doi.org/10.3390/molecules200611357
Molecules (2015) 20: 11357-11372
- Schneider J, Mielich-Süss B, Böhme R and Lopez D.
In vivo characterization of the scaffold activity of flotillin on the membrane kinase KinC of Bacillus subtilis
DOI: https://doi.org/10.1099/mic.0.000137
Microbiology (2015) 161: 1871-1887
- Wagner R, Kricks L and Lopez D.
Functional membrane microdomains organize signaling networks in bacteria
DOI: https://doi.org/10.1007/s00232-016-9923-0
Journal of Membrane Biology (2016) 250: 367-378
- Wermser Ch and Lopez D.
Purification of lipid rafts from bacterial membranes
DOI: https://doi.org/10.1007/8623_2015_49
Hydrocarbon and Lipid Microbiology Protocols (2016) 113-122
- Koch G, Wermser Ch, Acosta IC, Kricks L, Stengel ST, Yepes A and Lopez D.
Attenuating Staphylococcus aureus virulence by targetting flotillin protein scaffold activity.
DOI: https://doi.org/10.1016/j.chembiol.2017.05.027
Cell Chemical Biology (2017) 24: 845-857
- Garcia-Betancur JC, Goñi-Moreno A, Horger T, Schott M, Sharan M, Eikmeir J, Wohlmuth B, Zernecke A, Ohlsen K, Kuttler C and Lopez D.
Cell Differentiation Defines Acute and Chronic Infection Cell Types in Staphylococcus aureus.
DOI: https://doi.org/10.7554/eLife.28023.001
eLife (2017) 6: e28023
- García-Fernández E, Koch G, Fekete A, Stengel ST, Schneider J, Mielich-Süss B, Geibel S, Markert SM,Stigloher Ch and Lopez D.
Membrane Microdomain Disassembly Inhibits MRSA Antibiotic Resistance
DOI: https://doi.org/10.1016/j.cell.2017.10.012
Cell (2017) 171: 1354-1367
- Mielich-Süß B, Mietrach N, Hertlein T, Marincola G, Ohlsen K, Geibel S and Lopez D.
Flotillin scaffold activity contributes to type VII secretion system assembly in Staphylococcus aureus
DOI: https://doi.org/10.1371/journal.ppat.1006728
PLoS Pathogens (2017) 13: e1006728
- Lopez D and Koch G.
Exploring functional membrane microdomains in bacteria: an overview
DOI: https://doi.org/10.1016/j.mib.2017.02.001
Current Opinion in Microbiology (2017) 36: 76-84
- Diehl A, Roske Y, Ball L, Chowdhury A, Hiller M, Molière N, Kramer R, Stöppler D, Worth CL, Schlegel B, Leidert M, Cremer N, Erdmann N, Lopez D, Stephanowitz H, Krause E, van Rossum EB, Schmieder P, Heinemann U, Turgay K, Akbey U and Oschkinat H.
Structural changes of TasA in biofilm formation of Bacillus subtilis
DOI: https://doi.org/10.1073/pnas.1718102115
PNAS (2018) 15: 3237-3242
- Dragoš A, Martin M, Falcon Garcia C, Kricks L, Pausch P, Heimerl T, Horvath B, Maroti G, Bange G, Lopez D, Lieleg O and Kovács AT.
Collapse of genetic division of labour and evolution of autonomy in pellicle biofilms
DOI: https://doi.org/10.1038/s41564-018-0263-y
Nature Microbiology (2018) 3: 1451-1460
- Wermser CH and Lopez D.
Identification of Staphylococcus aureus genes involved in the formation of structured macrocolonies
DOI: https://doi.org/10.1099/mic.0.000660
Microbiology (2018) 164: 801-815
- Romero D, Traxler M, López D and Kolter R.
Antibiotics as Signaling Molecules
DOI: https://doi.org/10.1021/cr2000509
Chemical Reviews (2011) 111: 5492-5505
- Boehm A, Papenfort K, Lopez D and Vogel J.
Microbes at their Best: First Mol Micro Meeting Wuerzburg
DOI: https://doi.org/10.1111/j.1365-2958.2011.07852.x
Molecular Microbiology (2011) 82: 797-806
- Garcia-Betacur J.C, Yepes A, Schneider J and Lopez D.
Single-cell Analysis of Bacillus subtilis Biofilms Using Fluorescence Microscopy and Flow Cytometry
DOI: https://doi.org/10.3791/3796
Journal of visualized experiments (2012) 60: e3796
- Schneider J, Yepes A, Garcia-Betacur J.C, Westedt I, Mielich B and Lopez D.
Streptomycin-Induced Expression in Bacillus subtilis of YtnP, a Lactonase-Homologous Protein That Inhibits Development and Streptomycin Production in Streptomyces griseus
DOI: https://doi.org/10.1128/AEM.06992-11
Applied and Environmental Microbiology (2012) 78: 599-603
- Yepes A, Schneider J, Garcia-Betacur J.C, Mielich B Koch, G and Lopez D.
The biofilm formation defect of a Bacillus subtilis flotillin-defective mutant involves the protease FtsH
DOI: https://doi.org/10.1111/j.1365-2958.2012.08205.x
Molecular Microbiology (2012) 86: 457-471
- Audretsch C, López D, Srivastava M, Wolz C and Dandekar T.
A semi-quantitative model of Quorum-Sensing in Staphylococcus aureus, approved by microarray meta-analyses and tested by mutation studies
DOI: https://doi.org/10.1039/c3mb70117d
Molecular Biosystems (2013) 9: 2665 -2680
- Mielich-Suss B, Schneider J and Lopez D.
Overproduction of Flotillin Influences Cell Differentiation and Shape in Bacillus subtilis
DOI: https://doi.org/10.1128/mBio.00719-13
mBio (2013) 4: e00719
- Yepes A, Koch G, Waldvogel A, Garcia-Betancur JC and Lopez D.
Reconstruction of MreB expression in Staphylococcus aureus using a collection of new integrative plasmids
DOI: https://doi.org/10.1128/AEM.00759-14
Applied and Environmental Microbiology (2014) 80: 3868-3878
- Koch G, Yepes A, Förstner KU, Wermser C, Stengel S, Modamio S, Ohlsen K, Foster K and Lopez D.
Evolution of resistance to a last-resort antibiotic in Staphylococcus aureus via bacterial competition
DOI: https://doi.org/10.1016/j.cell.2014.06.046
Cell (2014) 158: 1060-1071
- López-Serrano D, Solano F and Sánchez-Amat A.
Involvement of a novel copper chaperone in tyrosinase activity and melanin synthesis in Marinomonas mediterranea
DOI: https://doi.org/10.1099/mic.0.2007/006833-0
Microbiology (2007) 153: 2241-2249
- Lopez D, Fischbach M, Chu F, Losick R and Kolter R.
Structurally Diverse Natural Products that Cause Potassium Leakage Trigger Multicellularity in Bacillus subtilis
DOI: https://doi.org/10.1073/pnas.0810940106
PNAS (2009) 106: 280-285
- Lopez D, Vlamakis H, Losick R and Kolter R.
Paracrine Signalling in a Bacterium
DOI: https://doi.org/10.1101/gad.1813709
Genes & Development (2009) 23: 1631-1638
- Lopez D, Vlamakis H, Losick R and Kolter R.
Generation of Multiple Cell types in Bacillus subtilis.
DOI: https://doi.org/10.1111/j.1574-6976.2008.00148.x
FEMS Microbiology Reviews (2009) 33: 152-163
- Lopez D, Vlamakis H, Losick R and Kolter R.
Cannibalism Enhances Biofilm Development in Bacillus subtilis
DOI: https://doi.org/10.1111/j.1365-2958.2009.06882.x
Molecular Microbiology (2009) 74: 609-618
- Lopez D, Vlamakis H, Losick R and Kolter R.
Extracellular Signals that Define Distinct and Coexisting Cell Fates in Bacillus subtilis.
DOI: https://doi.org/10.1111/j.1574-6976.2009.00199.x
FEMS Microbiology Reviews (2010) 34: 134-149
- Lopez D, Gontang E and Kolter R.
Potassium-Sensing Histidine Kinase in Bacillus subtilis.
DOI: https://doi.org/10.1016/S0076-6879(10)71013-2
Methods Enzymology (2010) 471: 229-251
- Lopez D, Vlamakis H and Kolter R.
Biofillms
DOI: https://doi.org/10.1101/cshperspect.a000398
Prokaryote Cell Biology. CSH Perspectives (2010) 2: a000398
- Lopez D and Kolter R.
Functional Microdomains in Bacterial Membranes
DOI: https://doi.org/10.1101/gad.1945010
Genes & Development (2010) 24: 1893-1902
Highlights: Nature Reviews Microbiology (2010) 8: 2455. Bacterial lipid rafts discovered
- Solano F, Lucas-Elío P, López-Serrano D and Sánchez-Amat A.
Dimethoxiphenol oxidase activity of different microbial multicopper proteins
DOI: https://doi.org/10.1111/j.1574-6968.2001.tb10882.x
FEMS Microbiology Letters (2001) 204: 175-181
- López-Serrano D, Sánchez-Amat A and Solano F.
Cloning and Molecular Characterization of a SDS-activated Tyrosinase from Marinomonas Mediterránea
https://doi.org/10.1034/j.1600-0749.2002.1o068.x
Pigment Cell and Melanoma Research (2002) 15: 104-111
- Hernández-Romero D, Lucas-Elío P, López-Serrano D, Solano F and Sánchez-Amat A.
Marinomonas mediterranea is a Lysogenic Bacterium that Synthesizes R-Bodies
DOI: https://doi.org/10.1099/mic.0.26524-0
Microbiology (2003) 149: 2679-2686
- López-Serrano D, Solano F and Sánchez-Amat A.
Identification of an operon involved in tyrosinase activity and melanin synthesis in Marinomonas mediterranea
DOI: https://doi.org/10.1016/j.gene.2004.08.003
Gene (2004) 342: 179-187
Patents
Inhibitors of biofilm formation
Patent number | WO2011031964
Publication Date | 17.03.2011
- Designated States | International patent
López D, Kolter R and Hatton B
New use of statins in overcoming resistance to β-lactam antibiotics in bacterial species synthetizing isoprenoids using the mevalonate synthetic pathway Issuing year
Patent number | WO2019086633
Publication Date | 2017
López D and Koch G
Scientific papers
- Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature | Nature Communications 13(1):7174 (2022)
Rodrigues Lopes I, Alcantara LM, Silva RJ, Josse J, Pedrero Vega E, Cabrerizo AM, Bonhomme M, Lopez D, Laurent F, Vandenesch F, Mano M, Eulalio A. DOI | Read More - Functional membrane microdomains and the hydroxamate siderophore transporter ATPase FhuC govern Isd-dependent heme acquisition in Staphylococcus aureus | Elife 12: e85304 (2022)
Adolf LA, Müller-Jochim A, Kricks L, Puls JS, Lopez D, Grein F, Heilbronner S. DOI | Read More - The Induction of Natural Competence Adapts Staphylococcal Metabolism to Infection | Nature Communications 13(1):1525 (2022)
Garcia J., Cordero M., Acosta I., Yepes A., Avedano J., Lisowski C., Ostereicht B., Ohlsen K., Collazo E., Föstner K., Eulalio A. and Lopez D.
DOI: 10.1038/s41467-022-29206-7 | Read More
- Substrate interaction with the EssC coupling protein of the Type VIIb secretion system | Journal of Bacteriology 202(7): e00646-19 (2020)
Mietrach N., Damián-Aparicio D., Mielich-Süß B., López D., and Geibel S.
DOI: 10.1128/JB.00646-19 | Read More - Cell Heterogeneity in Staphylococcal Communities |Journal of molecular biology 431(23):4699-4711 (2019)
García-Betancur J. C. and Lopez D.
DOI: 10.1016/j.jmb.2019.06.011 | Read More - Structural basis of denuded glycan recognition by SPOR domains in bacterial cell division | Nature communications 10:5567 (2019)
Alcorlo M., Dik D., De Benedetti S., Mahasenan K., Lee M., Dominguez-Gil T., Hesek D., Lastochkin E., Lopez D., Boggess W., Mobashery S., and Hermoso J.
DOI: 10.1038/s41467-019-13354-4 | Read More
- Collapse of genetic division of labour and evolution of autonomy in pellicle biofilms | Nature Microbiology. 2018 Dec;3(12):1451-1460 (2018)
Dragoš A., Martin M., Falcón-Garcia C., Kricks L., Pausch P., Heimerl T., Bálint B., Maróti G., Bange G., López D., Lieleg O., Kovács A. T.
DOI: 10.1038/s41564-018-0263-y | Read More - Structural changes of TasA in biofilm formation of Bacillus subtilis | PNAS 115 (13) 3237-3242 (2018)
Diehl A., Roske Y., Ball L., Chowdhury A., Hiller M., Molière N., Kramer R., Stöppler D., Worth C. L., Schlegel B., Leidert M., Cremer N., Erdmann N., López D., Stephanowitz H., Krause E., van Rossum E. B., Schmieder P., Heinemann U., Turgay K., Akbey U., Oschkinat H.
DOI: https://doi.org/10.1073/pnas.1718102115 | Read More - Identification of Staphylococcus aureus genes involved in the formation of structured macrocolonies | Microbiology SGM 164: 801-815 (2018)
Wermser C. H., López D.
DOI: https://dx.doi.org/10.1099/mic.0.000660 | Read More - Cell differentiation defines acute and chronic infection cell types in Staphylococcus aureus |eLIFE 6:e28023 (2017)
García-Betancur J.C., Goñi-Moreno A., Horger T., Schott M., Sharan M., Eikmeier J., Wohlmuth B., Zernecke A., Ohlsen K., Kuttler C., Lopez D.
DOI: https://doi.org/10.7554/eLife.28023.001 | Read More
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Patents
Inhibitors of biofilm formation
Patent number | WO/2011/031964
Publication Date | 17.03.2011
- Designated States | International patent
López D, Kolter R and Hatton B
Inhibitors of biofilm formation Issuing year: 2012
Patent number | USSN 61/241,342
Publication Date | 2012
- International patent | PCT/US10/48422
López D, Kolter R and Hatton B
New use of statins in overcoming resistance to β-lactam antibiotics in bacterial species synthetizing isoprenoids using the mevalonate synthetic pathway Issuing year
Patent number | WO2019086633
Publication Date | 2017
Lopez D and Koch G
