Publications

The outcomes of our research

Scientific papers

  • Adolf LA, Müller-Jochim A, Kricks L, Puls JS, Lopez D, Grein F, Heilbronner S*.
    Functional membrane microdomains and the hydroxamate siderophore transporter ATPase FhuC govern Isd-dependent heme acquisition in Staphylococcus aureus
    DOI: https://doi.org/10.7554/eLife.85304
    eLife 12: e85304 (2023)
  • Wessel AK, Yoshii Y, Reder A, Boudjemaa R, Szczesna M, Betton JM, Bernal-Bayard J, Beloin C, Lopez D, Völker U, b and JM Ghigo*. Escherichia coli SPFH Membrane Microdomain Proteins HflKC Contribute to Aminoglycoside and Oxidative Stress Tolerance
    DOI: https://doi.org/10.1128%2Fspectrum.01767-23
    Microbiology Spectrum 11: e01767-23 (2023).
  • Garcia J, Cordero M, Acosta IC, Yepes A, Avendano J, Lisowski C, Osterreicht B, Ohlsen K, Lopez-Collazo E, Föstner KU, Eulalio A and Lopez D*. The Induction of Natural Competence Adapts Staphylococcal Metabolism to Infection
    DOI: https://doi.org/10.1038/s41467-022-29206-7
    Nature Communications 13:1525 (2022)
  • Bencurova E, Shityakov S, Schaack D, Kaltdorf M, Sarukhanyan E, Hilgarth A, Rath C, Montenegro C, Roth G, Lopez D, Dandekar T*. Nanocellulose Composites as Smart Devices With Chassis, Light-Directed DNA Storage, Engineered Electronic Properties, and Chip Integration
    DOI: https://doi.org/10.3389/fbioe.2022.869111
    Frontiers in Bioengineering and Biotechnology 10:869111 (2022)
  • Rodrigues Lopes I, Alcantara LM, Silva RJ, Josse J, Pedrero Vega E, Cabrerizo AM, Bonhomme M, Lopez D, Laurent F, Vandenesch F, Mano M, Eulalio A*.
    Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature
    DOI: https://doi.org/10.1038/s41467-022-34790-9
    Nature Communications 13:7174 (2022)
  • Mietrach N., Damián-Aparicio D., Mielich-Süß B., López D., and Geibel S.
    Substrate interaction with the EssC coupling protein of the Type VIIb secretion system
    DOI: https://doi.org/10.1128/JB.00646-19
    Journal of Bacteriology 202(7): e00646-19 (2020)
  • Alcorlo M., Dik D., De Benedetti S., Mahasenan K., Lee M., Dominguez-Gil T., Hesek D., Lastochkin E., Lopez D., Boggess W., Mobashery S., and Hermoso J.
    Structural basis of denuded glycan recognition by SPOR domains in bacterial cell division
    DOI: https://www.nature.com/articles/s41467-019-13354-4
    Nature communications 10:5567 (2019)
  • Feng X, Hu Y, Zheng Y, Zhu W, Li K, Huang CH, Ko TP, Ren F, Chan HC, Nega M, Bogue S, Lopez D, Kolter R, Götz F, Guo RT and Oldfield E.
    Structure and function of Bacillus subtilis YisP: Biofilm production by a YisP product
    DOI: https://doi.org/10.1016/j.chembiol.2014.08.018
    Cell Chemical Biology (2015) 21: 1557-1563 
  • Schneider J, Klein, T, Mielich-Süß B, Franze C, Kuipers O, Kovacs A, Sauer M and Lopez D.
    Spatio-temporal remodeling of bacterial functional membrane microdomains
    DOI: https://doi.org/10.1371/journal.pgen.1005140 
    PLoS Genetics (2015) 11: e1005140 
  • Espina L, Pagán R, López D and García-Gonzalo D.
    Individual Constituents from Essential Oils Inhibit Biofilm Mass Production by Multi-Drug Resistant Staphylococcus aureus
    DOI: https://doi.org/10.3390/molecules200611357 
    Molecules (2015) 20: 11357-11372 
  • Schneider J, Mielich-Süss B, Böhme R and Lopez D.
    In vivo characterization of the scaffold activity of flotillin on the membrane kinase KinC of Bacillus subtilis
    DOI: https://doi.org/10.1099/mic.0.000137 
    Microbiology (2015) 161: 1871-1887
  • Koch G, Wermser Ch, Acosta IC, Kricks L, Stengel ST, Yepes A and Lopez D.
    Attenuating Staphylococcus aureus virulence by targetting flotillin protein scaffold activity.
    DOI: https://doi.org/10.1016/j.chembiol.2017.05.027 
    Cell Chemical Biology (2017) 24: 845-857
  •  Garcia-Betancur JC, Goñi-Moreno A, Horger T, Schott M, Sharan M, Eikmeir J, Wohlmuth B, Zernecke A,  Ohlsen K, Kuttler C and Lopez D.
    Cell Differentiation Defines Acute and Chronic Infection Cell Types in Staphylococcus aureus.
    DOI: https://doi.org/10.7554/eLife.28023.001  
    eLife (2017) 6: e28023 
  • García-Fernández E, Koch G, Fekete A, Stengel ST, Schneider J, Mielich-Süss B, Geibel S, Markert SM,Stigloher Ch and Lopez D.
    Membrane Microdomain Disassembly Inhibits MRSA Antibiotic Resistance
    DOI: https://doi.org/10.1016/j.cell.2017.10.012 
    Cell (2017) 171: 1354-1367 
  •  Mielich-Süß B, Mietrach N, Hertlein T, Marincola G, Ohlsen K, Geibel S and Lopez D.
    Flotillin scaffold activity contributes to type VII secretion system assembly in Staphylococcus aureus
    DOI: https://doi.org/10.1371/journal.ppat.1006728 
    PLoS Pathogens (2017) 13: e1006728 
  • Diehl A, Roske Y, Ball L, Chowdhury A, Hiller M, Molière N, Kramer R, Stöppler D, Worth CL, Schlegel B, Leidert M, Cremer N, Erdmann N, Lopez D, Stephanowitz H, Krause E, van Rossum EB, Schmieder P, Heinemann U, Turgay K, Akbey U and Oschkinat H.
    Structural changes of TasA in biofilm formation of Bacillus subtilis
    DOI: https://doi.org/10.1073/pnas.1718102115 
    PNAS (2018) 15: 3237-3242 
  • Dragoš A, Martin M, Falcon Garcia C, Kricks L, Pausch P, Heimerl T, Horvath B, Maroti G, Bange G, Lopez D, Lieleg O and Kovács AT.
    Collapse of genetic division of labour and evolution of autonomy in pellicle biofilms
    DOI: https://doi.org/10.1038/s41564-018-0263-y 
    Nature Microbiology (2018) 3: 1451-1460 
  • Wermser CH and Lopez D.
    Identification of Staphylococcus aureus genes involved in the formation of structured macrocolonies
    DOI: https://doi.org/10.1099/mic.0.000660 
    Microbiology (2018) 164: 801-815 
  • Garcia-Betacur J.C, Yepes A, Schneider J and Lopez D.
    Single-cell Analysis of Bacillus subtilis Biofilms Using Fluorescence Microscopy and Flow Cytometry
    DOI: https://doi.org/10.3791/3796 
    Journal of visualized experiments (2012) 60: e3796 
  • Schneider J, Yepes A, Garcia-Betacur J.C, Westedt I, Mielich B and Lopez D.
    Streptomycin-Induced Expression in Bacillus subtilis of YtnP, a Lactonase-Homologous Protein That Inhibits Development and Streptomycin Production in Streptomyces griseus
    DOI: https://doi.org/10.1128/AEM.06992-11  
    Applied and Environmental Microbiology (2012) 78: 599-603 
  • Yepes A, Schneider J, Garcia-Betacur J.C, Mielich B Koch, G and Lopez D.
    The biofilm formation defect of a Bacillus subtilis flotillin-defective mutant involves the protease FtsH
    DOI: https://doi.org/10.1111/j.1365-2958.2012.08205.x 
    Molecular Microbiology (2012) 86: 457-471 
  • Audretsch C, López D, Srivastava M, Wolz C and Dandekar T.
    A semi-quantitative model of Quorum-Sensing in Staphylococcus aureus, approved by microarray meta-analyses and tested by mutation studies
    DOI: https://doi.org/10.1039/c3mb70117d 
    Molecular Biosystems (2013) 9: 2665 -2680 
  • Mielich-Suss B, Schneider J and Lopez D.
    Overproduction of Flotillin Influences Cell Differentiation and Shape in Bacillus subtilis
    DOI: https://doi.org/10.1128/mBio.00719-13  
    mBio (2013) 4: e00719 
  • Yepes A, Koch G, Waldvogel A, Garcia-Betancur JC and Lopez D.
    Reconstruction of MreB expression in Staphylococcus aureus using a collection of new integrative plasmids
    DOI: https://doi.org/10.1128/AEM.00759-14 
    Applied and Environmental Microbiology (2014) 80: 3868-3878
  • Koch G, Yepes A, Förstner KU, Wermser C, Stengel S, Modamio S, Ohlsen K, Foster K and Lopez D.
    Evolution of resistance to a last-resort antibiotic in Staphylococcus aureus via bacterial competition
    DOI: https://doi.org/10.1016/j.cell.2014.06.046 
    Cell (2014) 158: 1060-1071 

 

  • López-Serrano D, Solano F and Sánchez-Amat A.
    Involvement of a novel copper chaperone in tyrosinase activity and melanin synthesis in Marinomonas mediterranea
    DOI: https://doi.org/10.1099/mic.0.2007/006833-0  
    Microbiology (2007) 153: 2241-2249 
  • Lopez D, Fischbach M, Chu F, Losick R and Kolter R.
    Structurally Diverse Natural Products that Cause Potassium Leakage Trigger Multicellularity in Bacillus subtilis
    DOI: https://doi.org/10.1073/pnas.0810940106 
    PNAS (2009) 106: 280-285
  • Lopez D and Kolter R.
    Functional Microdomains in Bacterial Membranes
    DOI: https://doi.org/10.1101/gad.1945010 
    Genes & Development (2010) 24: 1893-1902
    Highlights: Nature Reviews Microbiology (2010) 8: 2455. Bacterial lipid rafts discovered 
  • López-Serrano D, Sánchez-Amat A and Solano F.
    Cloning and Molecular Characterization of a SDS-activated Tyrosinase from Marinomonas Mediterránea
    https://doi.org/10.1034/j.1600-0749.2002.1o068.x 
    Pigment Cell and Melanoma Research (2002) 15: 104-111 
  • Hernández-Romero D, Lucas-Elío P, López-Serrano D, Solano F and Sánchez-Amat A.
    Marinomonas mediterranea is a Lysogenic Bacterium that Synthesizes R-Bodies
    DOI: https://doi.org/10.1099/mic.0.26524-0  
    Microbiology (2003) 149: 2679-2686 
  • López-Serrano D, Solano F and Sánchez-Amat A.
    Identification of an operon involved in tyrosinase activity and melanin synthesis in Marinomonas mediterranea
    DOI: https://doi.org/10.1016/j.gene.2004.08.003  
    Gene (2004) 342: 179-187 

Patents

Inhibitors of biofilm formation

  • Patent number | WO2011031964

  • Publication Date | 17.03.2011

  • Designated States | International patent

  • López D, Kolter R and Hatton B

New use of statins in overcoming resistance to β-lactam antibiotics in bacterial species synthetizing isoprenoids using the mevalonate synthetic pathway Issuing year

  • Patent number | WO2019086633

  • Publication Date | 2017

  • López D and Koch G

Scientific papers

  • Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature | Nature Communications 13(1):7174 (2022)
    Rodrigues Lopes I, Alcantara LM, Silva RJ, Josse J, Pedrero Vega E, Cabrerizo AM, Bonhomme M, Lopez D, Laurent F, Vandenesch F, Mano M, Eulalio A. DOI | Read More
  • Functional membrane microdomains and the hydroxamate siderophore transporter ATPase FhuC govern Isd-dependent heme acquisition in Staphylococcus aureus | Elife 12: e85304 (2022)
    Adolf LA, Müller-Jochim A, Kricks L, Puls JS, Lopez D, Grein F, Heilbronner S. DOI | Read More
  • The Induction of Natural Competence Adapts Staphylococcal Metabolism to Infection | Nature Communications 13(1):1525 (2022)
    Garcia J., Cordero M., Acosta I., Yepes A., Avedano J., Lisowski C., Ostereicht B., Ohlsen K., Collazo E., Föstner K., Eulalio A. and Lopez D.
    DOI: 10.1038/s41467-022-29206-7 | Read More
  • Substrate interaction with the EssC coupling protein of the Type VIIb secretion system | Journal of Bacteriology 202(7): e00646-19 (2020)
    Mietrach N., Damián-Aparicio D., Mielich-Süß B., López D., and Geibel S.
    DOI: 10.1128/JB.00646-19 | Read More
  • Cell Heterogeneity in Staphylococcal Communities |Journal of molecular biology 431(23):4699-4711 (2019)
    García-Betancur J. C. and Lopez D.
    DOI: 10.1016/j.jmb.2019.06.011 | Read More
  • Structural basis of denuded glycan recognition by SPOR domains in bacterial cell division | Nature communications 10:5567 (2019)
    Alcorlo M., Dik D., De Benedetti S., Mahasenan K., Lee M., Dominguez-Gil T., Hesek D., Lastochkin E., Lopez D., Boggess W., Mobashery S., and Hermoso J.
    DOI: 10.1038/s41467-019-13354-4 | Read More
  • Collapse of genetic division of labour and evolution of autonomy in pellicle biofilms | Nature Microbiology. 2018 Dec;3(12):1451-1460 (2018)
    Dragoš A., Martin M., Falcón-Garcia C., Kricks L., Pausch P., Heimerl T., Bálint B., Maróti G., Bange G., López D., Lieleg O., Kovács A. T.
    DOI: 10.1038/s41564-018-0263-y | Read More
  • Structural changes of TasA in biofilm formation of Bacillus subtilis | PNAS 115 (13) 3237-3242 (2018)
    Diehl A., Roske Y., Ball L., Chowdhury A., Hiller M., Molière N., Kramer R., Stöppler D., Worth C. L., Schlegel B., Leidert M., Cremer N., Erdmann N., López D., Stephanowitz H., Krause E., van Rossum E. B., Schmieder P., Heinemann U., Turgay K., Akbey U., Oschkinat H.
    DOI: https://doi.org/10.1073/pnas.1718102115 | Read More
  • Identification of Staphylococcus aureus genes involved in the formation of structured macrocolonies | Microbiology SGM 164: 801-815 (2018)
    Wermser C. H., López D.
    DOI: https://dx.doi.org/10.1099/mic.0.000660 | Read More
  • Cell differentiation defines acute and chronic infection cell types in Staphylococcus aureus |eLIFE 6:e28023 (2017)
    García-Betancur J.C., Goñi-Moreno A., Horger T., Schott M., Sharan M., Eikmeier J., Wohlmuth B., Zernecke A., Ohlsen K., Kuttler C., Lopez D.
    DOI: https://doi.org/10.7554/eLife.28023.001 | Read More
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Patents

Inhibitors of biofilm formation

  • Patent number | WO/2011/031964

  • Publication Date | 17.03.2011

  • Designated States | International patent

  • López D, Kolter R and Hatton B

Inhibitors of biofilm formation Issuing year: 2012

  • Patent number | USSN 61/241,342

  • Publication Date | 2012

  • International patent | PCT/US10/48422

  • López D, Kolter R and Hatton B

New use of statins in overcoming resistance to β-lactam antibiotics in bacterial species synthetizing isoprenoids using the mevalonate synthetic pathway Issuing year

  • Patent number | WO2019086633

  • Publication Date | 2017

  • Lopez D and Koch G